How grading works
Every intervention carries an evidence tier from A to C. Tier is never signalled by colour alone: each card states the level in text, shows a three-segment confidence meter, and carries a coloured top stripe as a secondary cue.
Featured interventions
7 of 73 recordsLongevity gene therapies. Selecting a card toggles it in the healthspan model, exactly as in the main list.
- Category: GenomicsGenomicsINT-0002
Telomerase Gene Therapy (AAV-hTERT)
Extended median lifespan in mice without raising cancer incidence in the original study; human use remains investigational and largely unregulated.
Illustrative range
+2 to +5 years
Level CEmerging evidence - Category: GenomicsGenomicsINT-0005
Klotho Gene Therapy
Higher Klotho associates with longevity and cognition in humans; delivery approaches (gene therapy, secretagogues) are preclinical.
Illustrative range
+2 to +8 years
Level CEmerging evidence - Category: GenomicsGenomicsINT-0009
FOXO3 Gene Therapy Research
Predominantly animal studies show promise for FOXO3 overexpression. Human clinical applications remain theoretical.
Illustrative range
+3 to +9 years
Level CEmerging evidence - Category: GenomicsGenomicsINT-0004
Follistatin Gene Therapy
Robust muscle-preserving effects in animal models; human use confined to small experimental programs.
Illustrative range
+2 to +5 years
Level CEmerging evidence - Category: GenomicsGenomicsINT-0010
SIRT1 Gene Therapy Research
Animal models show metabolic improvements and lifespan extension. Human translation in early development.
Illustrative range
+4 to +8 years
Level CEmerging evidence - Category: GenomicsGenomicsINT-0011
PGC-1α Gene Enhancement Research
Animal studies demonstrate enhanced mitochondrial function and exercise capacity. Human applications theoretical.
Illustrative range
+2 to +6 years
Level CEmerging evidence - Category: GenomicsGenomicsINT-0012
FGF21 Gene Therapy Research
Human FGF21 analogs show metabolic benefits. Gene therapy approaches aim for sustained expression.
Illustrative range
+3 to +8 years
Level CEmerging evidence